By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the previous years have visible quick development within the box of adenovirus study. additionally, adenoviruses have attracted huge curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune procedure, oncogenesis and gene treatment.
Read or Download Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy PDF
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Additional resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy
1994; Andersson et al. 1997). , the KDEL receptor Erd2p, is maintained by a dynamic process involving export from and recycling to the ER. Sorting at the TGN will be discussed in the following chapter, because the TGN seems to be closely connected to the endosomalllysosomal system, which utilizes similar targeting motifs. 1 Sorting Motifs, Adaptor Complexes, and Coat Proteins The TGN serves as a sorting station where proteins destined for the different post -Golgi compartments, the specialized secretory vesicles, the plasma membrane, and the endosomalllysosomal system are separated (Traub and Kornfeld 1997).
Overexpression of a dominant negative PACS-l mutant leads to a redistribution of furin and the cation-independent MPR (CI-MPR) from the TGN to a vesicular, most likely endosomal compartment, suggesting a role of PACS1 in endosome-TGN transport (Crump et al. 2001). lysosomal system (Gu and Gruenberg 1999) and have been proposed to be crucial for the biogenesis of so-called endocytic carrier vesicles, which are thought to transport proteins from early to late endosomes (Fig. 2). Not included in Table 2 are the various motifs implicated in targeting proteins to the apical membrane in polarized cells, such as N-glycans, O-glycans, TMDs, cytoplasmic peptides, and GPI-anchors (Rodriguez-Boulan and Gonzalez 1999).
J Mol Biol234:1308-1316 Delp K, Momburg F, Hilmes C, Huber C, Seliger B (2000) Functional deficiencies of components of the MHC class I antigen pathway in human tumours of epithelial origin. Bone Marrow Transplant 25:S88-S95 Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H (2001) Recruitment of TRRAP required for oncogenic transformation by EIA. Oncogene 20:8270-8275 Djeu JY, Jian K, Wei S (2002) A view to a kill: Signals triggering cytotoxicity. Clin Cancer Res 8:636-640 Evasion of the Immune System by Adenoviruses 23 Dobner T, Kzhyshkowska J (2001) Nuclear export of adenovirus RNA.